Detecting Outliers in Bioequivalence Studies for Crossover Design
نویسندگان
چکیده
منابع مشابه
Residuals and outliers in replicate design crossover studies.
Outliers in bioequivalence trials may arise through various mechanisms, requiring different interpretation and handling of such data points. For example, regulatory authorities might permit exclusion from analysis of outliers caused by product or process failure, while exclusion of outliers caused by subject-by-treatment interaction generally is not acceptable. In standard 2 x 2 crossover studi...
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In 2008, this group published a paper on approaches for two-stage crossover bioequivalence (BE) studies that allowed for the reestimation of the second-stage sample size based on the variance estimated from the first-stage results. The sequential methods considered used an assumed GMR of 0.95 as part of the method for determining power and sample size. This note adds results for an assumed GMR ...
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The ever-increasing volume of spatial data has greatly challenged our ability to extract useful but implicit knowledge from them. As an important branch of spatial data mining, spatial outlier detection aims to discover the objects whose non-spatial attribute values are significantly different from the values of their spatial neighbors. These objects, called spatial outliers, may reveal importa...
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ژورنال
عنوان ژورنال: Asian Journal of Applied Science and Technology
سال: 2020
ISSN: 2456-883X
DOI: 10.38177/ajast.2020.4103